When taken above the therapeutic dose, increased concentrations of ivermectin may overwhelm the ability of the P- glycoprotein pumps to keep it out of the CNS by saturating the pump. This can lead to neurotoxic effects such as ataxia, tremors, myoclonus, seizures, encephalopathy, and coma. What does ivermectin do to your brain?
Some of the products that may interact with this drug include: barbiturates (such as phenobarbital, butalbital), benzodiazepines (such as clonazepam, lorazepam), sodium oxybate (GHB), valproic acid. Does Ivermectin interact with other drugs you are taking? What to avoid when taking ivermectin?
Two applications of permethrin with a one week interval is more effective than a single dose of ivermectin. Two doses of ivermectin is as effective as a single application of permethrin. Is ivermectin better than permethrin?